纤维蛋白原编码区SNP与血栓性疾病地关系及机制_李积凤.pdf

20 10 10 O ct. 2010 3 1 5 Journal of C apitalM ed ical U niversity V o l. 31 N o. 5 [ do:i 10. 3969/ j. issn. 1006-7795. 2010. 05. 007] # # 纤维蛋白原编码区 SNP与血栓性疾病的关系及机制 1, 2, 3 1, 3* 1, 2, 3 李积凤 王 辰 王 军 1. , ; 2. ; 3. ) = , , , , sing le nucleotide po lymo rph ism, SN P ) SN P = ; ; ; ; ; ; = R 563; R 331 Single Nucleotide Polymo phism s in F ib inogen Coding Sequence and Th ombotic Diseases 1, 2, 3 1, 3* 1, 2, 3 L I J-i feng , WANG Chen , WANG Jun 1. D ep artm ent of R esp iratory and Critical CareM ed icine, B eij ing Chaoyang H osp ita,l Cap italM ed ical University, Beij ing Institute of Resp ira tory M edicine; 2. Departm ent of P hysiology, chool of Basic M edical ciences, Cap ital M ed ical University; 3. Faculty of Resp ira tory D isease, Cap italM ed ical University) = ABSTRACT A s the m ost abundant com ponen t o f coagulation system, f ibrinogen no t only takes part in clotting, but also w orks as one o f acute phase proteins. F ibr inog en partic ipates in m any physio log ica l and pathophysio log ica l processes through modu lating blood v iscosity, endo the lial function and prom otion o f sm ooth mu sc le ce ll pro lifera tion and m ig ra tion. It has been found that there are po sitive assoc ia tions be wt een the abnorm a l structure or function o f fibrinogen induced by sing le nucleotide po lym orphism s SNP ) in f ibr inog en cod ing sequences and m any k inds o f diseases, especially thrombotic d isorders. Th is rev iew summ ar ized the SNP in f ibr inog en co