新生儿机械通气与肺、脑耸丘害的长期随访-2011.ppt

新生儿机械通气与肺、脑发育及损害的随访及预防策略;新生儿呼吸衰竭NRF临床转归;Background;比较2004-2010年NRF多中心研究;范围;RDS Nation-wide Hebei Nation-wide% 2004 2007 2008;RDS1500g Nation Hebei Nation-wide% 2004 2007 2008;NICU distribution in NRF study;China GDP and population (2007);Participation centers in Hebei central cities;GA and BW distribution of NRF;100;Hebei GDP and population (2007);Hebei vs. nation-wide study;Hebei vs. nation-wide study;Hebei vs. nation-wide study;Complications;新生儿机械通气诱发肺损伤;;Acute and chronic lung injury;新生儿机械通气诱发脑损伤;Goulden First Hour of Postnatal Life;机械通气导致早产新生儿肺脑损害;;肺保护性通气策略;Lung and brain damage in preterm newbornsAre they related ? How ? Why ?;BPD = WMD脑白质损害;Prevalence of BPD (%) (%) Corioamnionitis Ventilation Sepsis;风险因素 低碳酸 高氧 延长通 病例/ OR 呼吸机 血症 血症 气时间 总数 % (95% CI) 0 0 0 0 6/257 2.3 1 + 0 0 0 14/228 6.1 2.7 (1.0, 8.1) 机械通气加一个风险因素 11/103 10.7 5.0 (1.6, 15.7) + + 0 0 3/33 9.1 4.2 (0.8, 20.3) + 0 + 0 1/22 4.5 2.0 (0, 17.6) + 0 0 + 7/48 14.6 7.1 (2.0, 25.5) 机械通气加二个风险因素 19/55 34.5 22.1 (7.7, 67) + + + 0 7/22 31.8 19.5 (5.1, 77) + + 0 + 4/11 36.4 23.9 (3.9, 127) + 0 + + 8/22 36.4 23.9 (6.4, 93) 机械通气加三个风险因素 8/14 57.1 55.8 (12.5, 270);;;;;; ;; Cytokine Ventilator Induced Lung Injury;肺保护性通气策略主要进展;潮气量;潮气量;PEEP;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;上机模式 触发同步;撤机模式 触发同步;触发同步;触发同步;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;RDS;肺保护性通气策略: CPAP;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.