几种常见面瘫患者血浆纤维蛋白原的检测.pdfVIP

中国耳鼻咽喉头颈外科12010竿5月，第 17 巷，第 5 期 ·-三噩 几种常见面瘫患者血浆纤维蛋白原的检测 李健京，李娟，刘永亮 (北京世纪坛医院耳鼻咽喉头颈外科面神经研究室，北京 100038) [摘要] 目的研究几种常见周围性面瘫患者的血浆纤 plasma fibrinogen and the pathogenesis of facial paralysis. 维蛋白原水平，并探讨其与面瘫发病机制之间的关系。方 METHODS A total of 157 inpatients with different kinds 法 选择 2006年 12 月 ~2008年 12 月在我科以面神经麻痹 of facial paralysis were studied from December 2006 to 为主要诊断入院的患者共计 157例按照病因及病情轻重分为 December 2008. They were etiologically divided into five Bell 麻痹重症组 60例， Bell ???痹轻症组 19例， Hunt综合征 groups: severe Bells palsy group (60 cases) , moderate 组28例、颤骨骨折组28例，肿瘤性面瘫组22例。入院后检 Bells palsy group (19 cases) , Ramsay-Hunt syndrome 测血浆纤维蛋臼原水平。结果 耳带状瘪葱、良性面神经 group (28 cases) , temporal bone fracture with facial 肿瘤、颗骨骨折、 Bell 麻痹轻症组患者血浆纤维蛋白原水平 palsy (28 cases) , and facial nerve tumor group (22 正常。 Bell 麻痹重症组纤维蛋白原水平 (4.08 :t 0.90) g/L 臼ses) . They were tested for plasma fibrinogen level right 明显高于其他各组，差异有统计学意义 (PO 日，且高于 after admitled to hospital. RESULTS Plasma fibrinogen 正常参考值范围 2.0~4.0 g/L 。结论病情严重的贝尔面瘫 level in severe Bells palsy group was (4.08 :t0.90) g/l, 患者血浆纤维蛋臼原水平升高，囱此产生的高凝状态将加 which was significantly higher than that in other groups 重面神经微循环障碍，可能是保守治疗无效的主要因素之 and the normal value (2.0~4.0) g/l (P0.05) . The -.Ej:带状范密、良性面神经肿瘤、额骨骨折患者血浆纤 other parameters of blood ∞agulation included PT, APTT, 维蛋白原水平正常。 Bell 麻痹轻症组水平正常，预示着纤维 and TT had no significantly difference among 5 groups. 蛋白原检测可能在贝尔面瘫预后方面有一定作用，建议作 CONCLUSION The level of plasma fibrinogen are 为