两种新辅助化疗方案治疗进展期胃癌的成本-效果评价.pdfVIP

.356. 中国综合临床 2010 年 4 月第药卷第 4 期 Clinical Medicine of China.2010. Vol. 26 .No. 4 ·论著· 两种新辅助化疗方案治疗进展期胃癌的 成本-效果评价 陈建时卢明东余小提郑志强 【摘要] 目的 评价两种新辅助化疗方案治疗进展期胃癌所产生的经济学效果。方法 2006 年 1 月 至 2α)9年 3 月我院收治的 53 例进展期胃癌患者分别接受氟尿喀咬+多西他赛+奥沙利钧 (A 方案组)和 FOLFOX4(B 方案组)新辅助化疗，观察其疗效~不良反应，并运用药物经济学的成本·效果分析法对两种方 案进行分析评价。结果 两种化疗方案的平均总成本分别为 21320.01 元和 17 158.50 元 z 化疗有效率为 57.14% (1 6/28) 和 52. ∞% (13/25) (P 0. 05) ;相应成本·效果比为 373. 12 和 329.97; 总不良反应发生率 为 82.14% (23/28) 和 76. ∞% (19/25) (P 0. 05) 。以 B 方案为基准，增量成本·效果为 809.63 。结论 B 方案是进展期胃癌新辅助化疗的较位用药方案。 【关键词] 胃肿瘪 z 新辅助化疗; 药物经济学; 成本·效果评价 A C08t-eftectiven棚 analy曲。，rtwo nl四a创 uvant chemotherapy schemωror advanωdgωtric cancer. CHEN Jian-hi ,LU Mi咱也啼，而 Xiao-tin.g ,ZHENG Zhi-qian.g. Department 0/ General Surgery , The Second 伊liated Hω-， pital (扩肌nzhou Medical College( Wenzhou 325027 , China) (Abs钮Bct] Obj氏tive To explore the c回t-effectiveness of two neoadjuvant chemotherapy schemes for the k回细lent of advanced gω创c cancer. Me曲ods Fifty-three patients from J皿.2αMωMar.2α)9 of advanced g.ωtric cancer underwent 由e neoadjuvant chemotherapy of Docetaxel + Oxaliplatin + FluorouTacil( scheme A) and FOLFOX4 (scheme 酌， repectively. 四erape四cef丑cacy and adverse 命吗 responses (ADRs) were observed. 四e pharmaco? economics of c佣t- effectiveness analysis w.ωperformed on two schemes 8s wel1. Results The costs were RMB 21320.01 归an for scheme A and RMB 17 158.50 归皿 for scheme B.ηle effective rat臼 were 57.149串 (16/组) in scheme A and 52. ∞% (13/25) in ?cheme B (P O. 05) , and the c咽 t-effectiveness ratio were 373. 12 and 329.97 per effective ra切 respectively. 四e ADRs rates were 82.14%