Mohnarin+2008年度报告 3a伤口感染细菌耐药性监测.pdf

中国抗牛素杂志2010年8月第35卷第8期 文章编号：1001-8689(2010)08—0602-07 Mohnarin 2008年度报告：伤口感染细菌耐药性监测 胡云建陶凤蓉郭芷萱 (卫生部北京医院，北京100730) 摘要：目的 了解2008年度全国89家医院中伤口感染处样本分离的细菌分布情况及对各类抗菌药物的耐药性。方法药物 敏感性试验采用纸片扩散法，耐药性数据分析采用WHONET 5．4软件进行统计分析。结果 共收集临床伤口感染处样本分离细 菌3388株，其中革兰阴性杆菌占50．5％，革兰阳性球菌占45．5％；前6位的菌种为凝固酶阴性葡萄球菌(CNS)(18．9％)，金黄色葡 萄球菌(16．1％)，大肠埃希菌(14．4％)，铜绿假单胞荫(10．1％)，肠球菌属(8．3％)，不动柑：菌属(7．2％)。体外药物敏感性试验结果显 示13．溶血链球菌未见青霉素耐药菌株；耐甲氧西林金葡菌(MRSA)和凝同酶阴性葡萄球菌分别为32．O％和74．6％。耐万占霉素的 粪肠球菌为0．7％，屎肠球菌为3．5％。大肠埃希萧超广谱B．内酰胺酶产酶率为53．3％，肺炎克雷伯菌为25．8％，变形菌属为5．4％， 发现对业胺培南耐药的肺炎克雷伯茵和肠杆菌属各1株。伤口感染已出现铜绿假单胞菌和不动杆菌属多重耐药株。结论 定期 进行耐药性监测有助于了解伤口感染细菌耐药性变迁，为临床经验用药提供理论依据。 关键词：伤口感染；细菌耐药性；抗菌药物；Molmarin：2008年 中图分类号：R378 文献标识码：A 2008 Mohnarin report：Bacterial resistance from wound infections Hu Yun-jian，Tao Feng—rong and Guo Zhi—xuan (Beijing Hospital，Ministry ofHealth，Beijing 100730) Abstract 0bjective To investigate the distribution and antibiotic resistance of clinical isolates bacteria from wound infections in 89 China hospital during 2008．Methods Antimicrobial susceptibility testing of clinical isolates was carried out by Kirby—Bauer methods and data were applied for analysis by WHONET5．4． Results 3388 clinical strains were isolated from wound infections．Gram positive cocci accounted for 45．5％，and gram negative bacilli 50．5％．The most predominant pathogens were coagulase—negative印hylococcus(1 8．9％)， StaphyloCOCCUS aureus(16．1％)，Escherichia coli(14．4％)，Pseudomonas aeruginosa(10．1％)，Enterococcus sp．(8．3％)， Acinetobacter spp(7．2％1．The drug resistance results show that no penicillin resistant 13-haemolytic streptococci were found；The detection rates of methicillin．resistant staphylococci were 32．0％in staphylococci aureus and 74．6％in coagulase．negative StaphyloCOCCUS．Vancomycin resistance Enterococcus in Enterococcus faecal船was 0．7％and in上沏terococcus faecium was 3．5％．ESBLs—producing strains accounted for 53．3％in E coli．25．8％in Klebsiella spp．and 5．4％in P阳teus mirabilis．One Klebsiella pneumoniae and one Enterobacter were found to be resistant to imipe