新生儿苍白球磁共振T1WI信号升高的原因分析-第三军医大学学报.doc

新生儿苍白球磁共振T1WI信号升高的原因分析 廖懿，蔡金华，重庆医科大学附属儿童医院放射科儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室重庆市儿童发育重大疾病诊治与预防国际科技合作基地重庆 400014) 中图分类号R445.2 [文献标志码A Analysis of hyperintensity of the globus pallidus on T1-weighted magnetic resonance images in newborns Liao Yi, Cai Jinhua, Zheng Helin (Department of Radiology, Children’s Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; Key Laboratory of Pediatrics in Chongqing; Chongqing International Science and Technology Cooperation Center For Child Development and Disorders, Chongqing 400014) [Abstract] Objective To explore the causes of symmetric hyperintensity of the globus pallidus on T1-weighted (T1WI) magnetic resonance images in newborns. Methods The brain magnetic resonance images of 427 cases of neonates were reviewed, and the T1WI signal patterns of the globus pallidus were qualitatively and quantitatively analyzed. Logistic regression analysis was applied to investigate contributions of the clinical factors to the hyperintensity of globus pallidus on T1WI. The signal intensity ratio of globus pallidus to cerebral cortex was compared with the total serum bilirubin (TSB) levels and the postnatal age at examination. Results T1WI hyperintensity of the globus pallidus was found in 249 of 427cases (58.3%). Logistic regression analysis showed that hyperbilirubinemia is a major factor of the hyperintensity of the globus pallidus on T1WI (OR=5.915, P0.001). With increasing of the TSB level, the signal intensity ratio of the globus pallidus to the cerebral cortex increased, with the difference statistically significant (χ2=84.734, P0.001). Correlation analysis showed that the signal intensity ratio of the globus pallidus to the cerebral cortex was negatively correlated with postnatal age at MRI examination (r=-0.441, P0.001). Conclusion Hyperbilirubinemia is a main factor contributing to the T1WI hyperintensity of globus pallidus in newborns. However, t