examquestionslectures3and4-riceuniversity（13页）.doc

BIOE 301/362 Name: Exam 2 March 13, 2008 The exam consists of 10 questions. Show all work to receive credit. Clearly organize your work and draw a box around your final answers. NEATNESS COUNTS! Good Luck! Problem 1 (5): Problem 2 (18): Problem 3 (12): Problem 4 (15): Problem 5 (8): Problem 6 (12): Problem 7 (12): Problem 8 (18): Extra Credit (4): Total (100): PROBLEM 1: Development of technology (5 points total) Eureka! You have just created what could be an HIV vaccine. Describe thesteps which you must undertake before you can obtain FDA approval to market this vaccine. Pre clinical testing in animals Phase I testing in healthy volunteers to monitor safety Phase II testing to monitor safety and efficacy Phase III testing to monitor safety and efficacy FDA submission for approval to market PROBLEM 2: Multiple choice. 3 pts each (18 points total). a. Bordetella pertussis and Influenza A virus are examples of respiratory pathogens; bacterial and viral, respectively. As such, they can both: Reproduce extracellularly, in saliva and lung fluids Be killed with antibiotics Reproduce inside lung cells Cause inflammation and coughing Answer:d (viruses can’t reproduce outside cells, or be killed with antibiotics, bordatella can’t reproduce inside lung cells, so the only common thing between them is causing inflammation) b. If a pathogen penetrates the skin barrier, which of the following action (s) will your immune system take as a first step to fight infection: Activate B-cells to generate antibodies against it Activate T-cell responses to kill infected cells Launch macrophages and inflammatory molecules to signal infection Release platelets to drive coagulation and prevent the pathogen from entering the blood flow Answer: c (innate imunity-macrophages and inflammation- is the first response after a skin barrier is bypassed) c. Durin