成人Still病如何诊治__培训课件.ppt

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成人Still病如何诊治__培训课件.ppt

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38例发热的AOSD患者（10M，28F，39.3y/o） 12例存在明确的细菌感染 26例活动的无感染AOSD患者（活动评分≥3）符合Yamaguchi标准检测PCT、CRP、IL-6、TNF-α 目前至少有7套诊断标准，大多数都是上述典型症状和化验的组合， but Who is the best？ Peking Union Medical College Hospital * 参考文献 1. Reginato AJ, Schumacher HR, Jr., Baker DG, OConnor CR, Ferreiros J. Adult onset Stills disease: experience in 23 patients and literature review with emphasis on organ failure. Semin Arthritis Rheum 1987;17:39-57. 2. Efthimiou P, Georgy S. Pathogenesis and management of adult-onset Stills disease. Semin Arthritis Rheum 2006;36:144-52. 3. Kotter I, Wacker A, Koch S, et al. Anakinra in patients with treatment-resistant adult-onset Stills disease: four case reports with serial cytokine measurements and a review of the literature. Semin Arthritis Rheum 2007;37:189-97. 4. Sabnis GR, Gokhale YA, Kulkarni UP. Tocilizumab in refractory adult-onset Stills disease with aseptic meningitis--efficacy of interleukin-6 blockade and review of the literature. Semin Arthritis Rheum 2011;40:365-8. 5. Colina M, Zucchini W, Ciancio G, Orzincolo C, Trotta F, Govoni M. The evolution of adult-onset still disease: an observational and comparative study in a cohort of 76 italian patients. Semin Arthritis Rheum 2011;41:279-85. 6. Elkon KB, Hughes GR, Bywaters EG, et al. Adult-onset Stills disease. Twenty-year followup and further studies of patients with active disease. Arthritis Rheum 1982;25:647-54. 7. Cush JJ, Medsger TA, Jr., Christy WC, Herbert DC, Cooperstein LA. Adult-onset Stills disease. Clinical course and outcome. Arthritis Rheum 1987;30:186-94. 8. Kawaguchi Y, Terajima H, Harigai M, Hara M, Kamatani N. Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Stills disease. Arthritis Rheum 2001;44:1716-7. 9. Iwamoto M, Nara H, Hirata D, Minota S, Nishimoto N, Yoshizaki K. Humanized monoclonal anti-interleukin-6 receptor antibody for treatment of intractable adult-onset Stills disease. Arthritis Rheum 2002;46:3388-9. 10. Husni ME, Maier AL, Mease P