老年肺结核新型化疗方案疗效及对肝脏近期损害的观察.docVIP

老年肺结核新型化疗方案疗效及对肝脏近期损害的观察 　　doi：10.3969/j.issn.1007-614x.2014.12.24 　　摘 要 目的：研究老年肺结核新型化疗方案疗效及对肝脏的近期损害。方法：2011年6月-2013年6月收治肺结核疾病患者76例，随机分为试验组和对照组，各38例。对照组实行抗结核板式组合药物等进行治疗；试验组实行将两种以上抗结核药按一定的剂量制成的抗结核固定复合制剂（以下简称FDC）进行化疗治疗。结果：在完成整个治疗后，试验组的痰菌转阴率92%，对照组75%。两组比较差异具有统计学意义（P0.05）。试验组有2例患者出现肝脏损害，对照组有4例患者出现肝脏损害。对所有患者进行相关的肝脏损害治疗后，患者的转氨酶均得到了有效控制。结论：FDC新型化疗方案治疗老年肺结核具有良好的治疗效果，搭配治疗可以减轻患者在化疗中产生的不良反应，更加安全可靠，同时也具有良好的耐受性，值得在实际临床中推广。 　　关键词 老年肺结核 新型化疗方案 肝脏近期损害 　　Observation of efficacy and recent damage of liver of new chemotherapy in the treatment of senile pulmonary tuberculosis 　　Li Qingbiao，Mohetaer?Aimaier 　　Department of Tuberculosis Prevention and Control，the Disease Control and Prevention Center of Awati County，Xinjiang 843200 　　Abstract Objective：To explore the efficacy and recent damage of liver of new chemotherapy in the treatment of senile pulmonary tuberculosis.Methods：76 patients with pulmonary tuberculosis were selected from June 2011 to June 2013.They were randomly divided into the experimental group and the control group with 38 cases in each.The control group received the treatment of anti tuberculosis drugs of plate type combination.The experimental group had the chemotherapy treatment of an anti tuberculosis fixed compound（hereinafter referred to as FDC）.This formulation was made with more than two kinds of anti TB drugs according to certain dose.Results：On completion of the treatment，the sputum negative conversion rate of the experimental group was 92%，that of the control group was 75%.There were statistically significant differences between the two groups（P0.05）.The experimental group had 2 patients with liver damage，the control group had 4 patients with liver damage.Transaminase of patients were effectively controlled after treatment of liver damage.Conclusion：Chemotherapy of FDC model has a good treatment effect in the treatment of senile pulmonary tuberculosis.Combination treatment can reduce the adverse reaction of patient in chemotherapy.It is more sec