SCLEROGLUCAN(倒и翅).ppt.ppt

SCLEROGLUCAN 授課老師：江文德教授 學生：孫慧吟 學號：2006/10/27 Production 硬葡聚糖 (Scleroglucan) Sclerotium spp. (Fungi) – Sclerotium rolfsii – Sclerotium glucanianm Process – D-glucose, NO3-, NH4+ – aerobic, pH3.5~5.5, 25~35℃, 2~6d – exopolysaccharide, 10~20g/L – native and refined Structure Homopolysaccharide – β(1→3)-D-glucopyranosyl β(1→6)-D-glucopyranosyl – DB=0.33 – Mw=5.4×106 (Da) Rod-like triple helix Properties High yield value and viscosity high suspension power Properties High yield value and viscosity high suspension power shear-thinning (pseudoplastic) Anti-settling properties Properties High yield value and viscosity Anti-settling properties Extremely effective in holding particles in suspension, in static as well as in dynamic conditions, without the risk of sedimentation. Properties High thermal stability 15~90°C remain constant 10°C, solutions have a semi-gelled appearance Sterilize by heating at 121°C for 20 hours ~7°C, thermoreversible Properties Compatibilities Non-ionic character Not affected by pH2.5~12 and electrolytes No synergism with other gels Applications Industry 油田上的應用 具良好分散性，控制流體之流動性、泥漿增稠劑等 造紙業、印染業、化妝品業、黏著劑、起泡劑等 Food industry 食品: 冷凍食品、甜點、烘陪食品、即溶奶粉、醬 汁、食用油等。 ex: 0.25% scleroglucan in vegetable oil 醫藥: 瀉藥、藥片包覆層、藥膏藥水等 Applications Antitumor 近年來許多研究皆指向以β(1-3)D-glucan為主鏈之多醣體具有抗腫瘤活性，可活化身體的免疫系統機能，因此被稱為biological response modifier (BRM)。 具triple helix結構，主鏈上的取代基種類並不會影響其功能性。Mw=1~2×105 (Da)最具活性 以β(1-3)D-glucan為主鏈並接β(1-6)D-glucan支鏈，形成梳狀結構，DB=0.2~0.33為活性最佳 促進巨噬細胞、T cell、NK cell 的活性 Applications 研究中發現，多醣體的抗腫瘤活性與分子量、支鏈度、分子構形及聚葡萄醣的三級結構(Tertiary structure)有關。但這些結構特性與抗腫瘤活性間的關連，仍有許多爭議。 References Industrial Gums, Third Edition J.A. Bohn, J.N. BeMiller, (1→3)-β-D-Gluvans as biological response modifiers: a review of structure-functional activity relationships, Carbohydr. Polym. 28 (1995) 3-14. B.H. Falch, T. Espevik, L. Ryan, B.T. St