乙烯基碳上的亲核取代反应有机化学.pdfVIP

DOI: 10.6023/cjoc201406046 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 乙烯基碳上的亲核取代反应 沈舒苏 (苏州科技学院分离净化材料与技术研发中心 苏州 215009) 摘要 综述了近二十年来关于sp2 杂化碳, 主要是乙烯基碳上发生的亲核取代反应的研究进展. 讨论了乙烯基碳上的亲 核取代反应的理论支持, 阐明了其在有机合成中, 特别是在杂环化合物的合成中的重要应用. 同时还总结了其他不饱 和原子如 sp2 杂化氮的亲核取代反应的研究以及应用. 关键词 乙烯基碳; sp2 2 杂化碳; 亲核取代反应; sp 杂化氮 Nucleophilic Substitution Reactions at Vinylic Carbons Shen, Shusu (a Center for Separation and Purification Materials Technologies, Suzhou University of Science and Technology, Suzhou 215009) 2 Abstract The recently research progress in the nucleophilic substitution reactions at the sp -carbons, mainly at the vinylic carbons is reviewed. The theoretical studies on the nucleophilic substitution reactions at the vinylic carbons, and their applica- tions in organic synthesis, especially in the synthesis of heterocycle compounds, are illustrated. And, researches and applica- 2 tions of the nucleophilic substitution reactions at other unsaturated atoms like sp nitrogens are also discussed. 2 2 Keywords vinylic carbon; sp carbon; nucleophilic substitution reaction; sp nitrogen [1] 亲核取代反应 在有机化学中是一类非常基础的反 H 1.78 Å H H 1.73 Å 3.0