《2016Omega-3 and omega-6 fatty acid exposure》.pdf

Environmental and occupational respiratory disorders Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years Catarina Almqvist, MD, PhD,a,b,c Frances Garden, BAppSci,d Wei Xuan, MSc, PhD,a Seema Mihrshahi, MPH,e Steve R. Leeder, MD, PhD,b Wendy Oddy, PhD,f Karen Webb, MPH, PhD,b and Guy B. Marks, MBBS, PhDa,b,c for the CAPS team Sydney and Perth, Australia, and Stockholm, Sweden Background: The Childhood Asthma Prevention Study was a levels, dietary intake, and compliance with supplements, was randomized controlled trial conducted in children with a family not associated with any respiratory or allergic outcomes history of asthma in whom omega-3 fatty acid supplementation (P 5 .35-.59). and restriction of dietary omega-6 fatty acids did not prevent Conclusion: This observational analysis of the cohort, using asthma, eczema, or atopy at age 5 years. the full range of observed variation in omega-3 and omega-6 Objective: We sought to examine the relation of all measures fatty acid exposure, supports the negative findings of the of omega-3 and omega-6 polyunsaturated fatty acids with randomized controlled trial. outcomes at age 5 years in the whole birth cohort, regardless Clinical implications: Modification of dietary polyunsaturated of randomization group. fatty acids in early childhood is not helpful in preventing atopy o