5二茂铁基异酞酰氨基酸甲酯的合成表征及电化学阴离子识别性能研究.pdfVIP

Syntheses, Characterizations and Electrochemical anion recognition investigations of new N-5-ferrocenylisophthalic 1 amino acid methyl esters Liu Wei, Hao Xinqi, Li Xia, Zhang Maolin, Song Maoping Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou, P.R. China (450052) E-mail: maopingsong@ Abstract A series of novel N-5-ferrocenylisophthalic amino acid methyl esters 3a-b were prepared via directly condensation reactions of 5-ferrocenylisophthalic dichloride to the amino acid methyl esters. The compounds were fully characterized by a range of NMR spectroscopic techniques, mass spectrometry (ESI-MS) and cyclic voltammetry. The CV curves of compounds 3a-b showed quasi-reversible redox behavior similar to the Fc/Fc+ redox couple, and electrochemical anions binding studies of 3a-b revealed that it has good ability in recognizing of various anions. Further, 1H NMR anion complexation studies of 3a-b with F- and H PO - strongly suggest the contribution of amide CONH protons and Ar-H 2 4 of isophthalyl as the hydrogen donors in anion binding in CDCl3 solution. Keywords: Ferrocene; Bioorganometalic chemistry; anion recognition; CV; 1H NMR coordination Over the past few decades, bioorganometallic chemistry, which links classical organometallic chemistry to biology, medicine, and molecular biotechnology, has developed as a rapidly growing and maturing area due to its potential application in preparing unnatural drugs, novel biosenso