2000-2009年我国北京和上海地区Hp抗生素耐药趋势研究.ppt

2000-2009年我国北京和上海地区Hp抗生素耐药趋势研究.ppt

  1. 1、本文档共26页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
Introduction Resistance of H. pylori to antibiotics is the main reason for the failure of therapies for H. pylori-associated diseases. Since the initial eradication of H. pylori can no longer be achieved due to its increasing resistance to antibiotics, it is necessary to investigate the local resistance of H. pylori to antibiotics for choosing the effective therapy for H. pylori-associated diseases. Introduction Department of Gastroenterology, Peking University First Hospital and Department of Gastroenterology, Shanghai Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine studied the resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Beijing and Shanghai, China. BACKGROUND As culture-based antimicrobial susceptibility data are not always available and the?H.?Pylori eradication regimen especially antibiotics involved should be chosen based on local resistant epidemiologic data and an empirical basis, it is important to understand the regional antibiotics resistance status and trend of this bacterium. OBJECTIVES To evaluate?Helicobacter?pylori?antibiotics? resistance?evolution?from 2000 to 2009 to amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin and moxifloxacin in?Beijing,?China. METHODS A total of 374 H.?pylori?strains isolated from 374 subjects who had undergone upper gastrointestinal endoscopy from 2000 to 2009 were collected and examined by E-test method for?antibiotics?susceptibility. RESEULTS The average?antibiotics?resistance?rates were 0.3% (amoxicillin), 37.2% (clarithromycin), 63.9% (metronidazole), 1.2% (tetracycline), 50.3% (levofloxacin) and 61.9% (moxifloxacin). Overall?resistance?to clarithromycin, metronidazole, and fluoroquinolone increased annually (from 14.8 to 65.4%, 38.9 to 78.8%, and 27.1 to 63.5%, in 2000 or 2006-2007 to 2009, respectively). RESULTS The secondary?resistance?rates were much higher than primary rates to these?antibiotics, which a

文档评论(0)

qujim + 关注
实名认证
内容提供者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档