埃索美拉唑联合莫沙必利治疗反流性食管炎90 例[J].pdfVIP

. 2010年2月第5卷第6期 China Prac Med，Fe ： ： -39· · 短篇论著 · 埃索美拉唑联合莫沙必利治疗反流性食管炎90例 江汉龙 钟世顺 金峰 郑国凡 叶建鸿 【摘要】 目的 观察埃索美拉唑联合莫沙必利治疗反流性食管炎的疗效。方法 将90例患者随 机分为治疗组(45例)和对照组(45例)。治疗组：埃索美拉唑40 mg，1次／d；莫沙必利5 mg，3次／d口 服。对照组：埃索美拉唑40 mg，1次／d口服。治疗前及治疗后2、4、6周计算患者症状积分。治疗后6 周复查胃镜，观察胃镜下愈合率。结果 治疗组临床有效率为100％，内镜下有效率为97．8％；对照组分 别为86．7％和84．4％，两组比较差异有显著性(P0．05)。结论 埃索美拉唑联合莫沙必利治疗反流 性食管炎比单用埃索美拉唑具有更好的疗效。 【关键词l 埃索美拉唑；莫沙必利；反流性食管炎 Esomeprazole combined with mosapride therapy for 90 cases of reflux esophagitis JIANG Han—long． ZHONG Shi—shun，jIN Feng，et a1．Department of Gastroenterology， 476th Clinical Branch of PLA，Fuzhou 350002，China 【Abstract】Objective To study the effect of esomeprazole and mosapride on treatment of reflux esoph— a tis(RE)．Methods 90 RE patients were randomly divided into tWO groups，the treatment group(45 ca- ses)：5 mg of mosapride tid，20 mg of esomeprazole qd were taken orally；the control group(45 cases)：20 mg esomeprazole qd were taken orally．The symptoms were evaluated from pretreatment to every two weeks after the treatment．The endoscope findings at the end of 6 weeks were recheched．Results The clinical curative rates were 100％ in the treatment group and 86．7％ in the control group．the efficient rate evaluation under endo— scope were 97．8％，84．4％respectively．There was significant difference between the two groups(P0．05) ． Conclusion The effect of esomeprazole combined with mosapride on treating the reflux esophagitis was obvi- ously superior to the other group． 【Key words】Esomeprazole；Mosapride；Reflux esophagitis 反流性食管炎(reflux esophagitis，RE)是消化系统常见的 明显，不能忍受，需休息及药物治疗者记3分。无症状发生记 疾病。其发病机制是由于多种因素导致的上消化道运动障 0分；每月发生记1分；每周发生记2分；每天发生记3分。治 碍，胃、十二指肠内容物反流入食管而引起的食管黏膜的破损 疗开始后，每2周随访1次，观察症状改善情况。 所致。质子泵抑制剂是目前治疗RE最有效的药物之一。埃 症状疗效判定标准：①显效：临床症状积分降低